Methyl(3-isothiocyanatopropyl) sulfoxide
Iberin
CAS: 505-44-2
Molecular Formula: C5H9NOS2
Methyl(3-isothiocyanatopropyl) sulfoxide - Names and Identifiers
Methyl(3-isothiocyanatopropyl) sulfoxide - Physico-chemical Properties
| Molecular Formula | C5H9NOS2 |
| Molar Mass | 163.26 |
| Density | 1.142 (estimate) |
| Boling Point | 240.37°C (rough estimate) |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Appearance | Oil |
| Color | Colourless |
| Storage Condition | Hygroscopic, Refrigerator, under inert atmosphere |
| Stability | Moisture Sensitive |
| Refractive Index | 1.5237 (estimate) |
| Physical and Chemical Properties | Bioactive Iberin (NSC 3218001) is a sulforaphane analog of sulforaphane, a member of the naturally occurring isothiocyanate family. The IC50 value for inhibition of HL60 cells was 2.3 μm. Iberin induces apoptosis. |
| Target | Human Endogenous Metabolite |
| In vitro study | Iberin inhibits the growth of neuroblastoma cells in a dose- and time-dependent manner. The iberin-induced cell cycle arrest in neuroblastoma cells is associated with inhibition of expression of cyclin-dependent kinase Cdk2, Cdk4, and Cdk6 proteins. There is an increase in apoptotic cell death in iberin treated cells as compared with control cells. The iberin-induced apoptosis is found to be associated with activation of caspase-9, caspase-3, and PARP. Iberin inhibits growth of human glioblastoma cells in cell proliferation assays, enhances cytotoxicity, and induces apoptosis by activation of caspase-3 and caspase-9. |
| In vivo study | Iberin is tested in an in vivo foreign-body infection mouse model, and the results show no significantly difference in bacterial clearance between treated and nontreated miced. Iberin increases tissue levels of the phase II detoxification enzymes quinone reductase and glutathione S-transferase in a variety of rat tissues. |
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CAS: 505-44-2
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CAS: 505-44-2
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View History
Methyl(3-isothiocyanatopropyl) sulfoxide
2-methyl-benzoicaci
HIS(DEAMINO)-OH
2-氧化吲哚-6-甲酸甲酯
N-甲基-L-丙氨酸
二氯乙酸甲酯
2-methyl-benzoicaci
HIS(DEAMINO)-OH
2-氧化吲哚-6-甲酸甲酯
N-甲基-L-丙氨酸
二氯乙酸甲酯